Psychotic major depressive disorder and rapid eye movement sleep behavior disorder cooccurring with a pineal cyst: a case report with neuroimaging insights in a 15-year-old female.

ABSTRACT:

Background

Pineal cysts are generally incidental findings on neuroimaging, yet recent evidence has suggested potential associations with circadian rhythm disruption, mood disorders, and sleep dysfunction. This report aims to describe a rare case in an adolescent to explore the potential association between pineal gland abnormalities and circadian dysregulation in the pathophysiology of mood and sleep disturbances.

Case presentation

We describe a 15-year-old female with a three-year history of depressive symptoms, auditory and visual hallucinations, persecutory delusions, and recurrent self-harm, culminating in multiple suicide attempts. On admission, brain magnetic resonance imaging (MRI) revealed a 7-mm pineal cyst. During hospitalization, polysomnography confirmed rapid ey

SUBMITTER: Shu Y 

PROVIDER: S-EPMC12751266 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature