Structural and dynamic insights into F13L variations in monkeypox virus and their impact on tecovirimat resistance.

ABSTRACT: The recent global outbreak of Monkeypox virus since 2022, particularly outside Africa, has underscored its significant threat to public health. Genomic surveillance from multiple countries has revealed diverse genetic variations among circulating Monkeypox virus strains. Notably, a common F13L (E353K) mutation was identified in strains responsible for concentrated outbreaks in the United Kingdom and North America. The F13L is the current target of the only approved drug for poxvirus treatment, tecovirimat (previously known as ST-246), Previous studies have reported that the F13L (G277C) mutation significantly increases resistance. However, the impact of the shared F13L (E353K) mutation on viral transmission and its potential role in conferring tecovirimat resistance remains unclear. To add

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12751290 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature