P75NTR alleviates diabetic periodontitis in mice by inhibiting inflammatory macrophage recruitment.

ABSTRACT:

Background

Periodontitis is a common oral health condition that is closely related to systemic diseases such as diabetes.The p75 neurotrophin receptor (p75NTR) belongs to the tumor necrosis factor receptor superfamily members of the neurotrophic factor low affinity receptor, which can regulate various metabolic and inflammatory diseases by activating immune cells, including macrophages and monocytes. Additionally, it plays a regulatory role in inflammatory diseases related to diabetes. Maxillary tissue-derived macrophages are crucial components of the immune defense in periodontal tissues.The aim of this experiment was aimed at investigating the effects and potential mechanisms of p75NTR on macrophages in a murine model of diabetic periodontitis.

Methods

The p75NTR wild-type

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12751326 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature