Associations of serum bile acids and amino acids with low skeletal muscle mass among Chinese population: a cross-sectional study.

ABSTRACT:

Background

Sarcopenia, characterized by progressive muscle loss, burdens aging populations. While bile acids (BAs) in skeletal muscle mass (SMM) are poorly understood, the role of amino acids (AAs) remains debated. This study investigated the associations between serum BAs, AAs, and low SMM in Chinese adults.

Methods

Among 2170 initially enrolled participants, 702 were finally analyzed. Participants were classified into low and normal SMM groups. Serum BAs and AAs were quantified by targeted LC-MS/MS. Nonlinear relationships were assessed using restricted cubic spline analysis. Mediation analysis was used to assess the mediating effects of metabolic factors.

Results

The prevalence of low SMM was 14.5% (females: 21.1% vs. males: 10.2%). Multivariable logistic regressio

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12751332 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature