Polymorphism-driven transcriptomic changes in anthelmintic metabolism pathways of Anisakis simplex s.s. L3 larvae.

ABSTRACT:

Background

Helminth infections continue to pose major challenges in human and veterinary medicine, with additional complications arising from the emergence of anthelmintic resistance. Anisakis simplex sensu stricto (A. simplex s.s.), a zoonotic nematode transmitted through the consumption of fish, is of growing concern due to its allergenic potential and clinical relevance. However, the molecular mechanisms underlying the parasite's response to anthelmintic treatment remain poorly defined.

Methods

Third-stage larvae (L3) of A. simplex s.s. were exposed to three widely used anthelmintics: albendazole (ALB), ivermectin (IVC) and pyrantel (PYR). High-throughput RNA sequencing was combined with differential gene expression, multivariate alternative splicing analysis (Replicate M

SUBMITTER: Mazdziarz M 

PROVIDER: S-EPMC12751375 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature