Left ventricular hypertrabeculation is a novel predictor of life-threatening arrhythmic events in long QT syndrome patients.

ABSTRACT:

Background

Long QT syndrome (LQTS) is a malignant cardiac channelopathy for patients with traditionally normal heart structures. Sporadic cases reported left ventricular hypertrabeculation (LVHT) was a deadly double hit in LQTS patients. Here we summarize the prevalence of LVHT within LQTS subjects and analyse the correlation of LVHT with life-threatening arrhythmic events (LAEs).

Methods

The study cohort consisted of 170 genotype-confirmed LQTS patients, which were classified to two groups, including non-left ventricular hypertrabeculation LQTS patients(LQTS-N-LVHT group) and LQTS-LVHT co-phenotype individuals (LQTS-LVHT group) according to the diagnosis criteria of LVHT. The primary endpoint was LAEs, defined as arrhythmogenic syncope, sustained ventricular tachycardia (VT

SUBMITTER: Yang J 

PROVIDER: S-EPMC12751391 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature