Remodeling gut microbiota and enhancing SCFA production in mice: mechanisms of RS2 and arabinoxylan in ameliorating PCOS phenotypes.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is linked to hyperandrogenism and gut microbiota dysbiosis. Dietary fibers (DFs), such as resistant starch type 2 (RS2) and arabinoxylan (AX), modulate the gut microbiota and produce short-chain fatty acid (SCFA), potentially ameliorating PCOS symptoms. This study investigated the therapeutic potential of RS2 and AX in a mouse model of letrozole-induced PCOS and explored the underlying mechanisms involving the gut microbiota-SCFA-liver signaling pathways.

Methods

Letrozole-induced PCOS mice were divided into six groups: control (C), RS2 (R), AX (A), PCOS model (M), RS2-treated PCOS (RM), and AX-treated PCOS (AM) groups. The interventions lasted 35 days. Body weight, glucose tolerance, insulin resistance, ovarian morphology, estrous

SUBMITTER: Liang Y 

PROVIDER: S-EPMC12751393 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature