EZH1 Inhibition attenuates apoptosis and promotes regeneration for liver repair in acute liver failure.

ABSTRACT:

Background

Acute liver failure (ALF) is a life-threatening clinical syndrome characterized by massive hepatocyte death and insufficient regenerative response. However, the epigenetic mechanisms that disturb the balance between cell death and regeneration remain largely unclear.

Materials and methods

We integrated transcriptomic data from public ALF patient cohorts, a CCl₄-induced murine ALF model, and an APAP-induced murine ALF model. Bioinformatic analyses included single-sample gene set enrichment analysis (ssGSEA) and weighted gene co-expression network analysis (WGCNA). The functional role of EZH1 was validated using EZH1 knockout mice, and liver injury was evaluated by serum biochemistry, histopathology, and immunohistochemistry.

Results

Integrated transcriptomic

SUBMITTER: You Y 

PROVIDER: S-EPMC12751407 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature