HDM and mannose as novel tolerogenic inducers for dendritic cells: mTOR/PPARγ-mediated attenuation of allergic asthma.

ABSTRACT: Dendritic cells (DCs) are pivotal in balancing immunity and tolerance in allergic asthma. This study reveals that both house dust mite (HDM) and mannose induce a potent tolerogenic phenotype in bone marrow derived DCs (BMDCs). These DCs display hallmark tolerogenic features, including a reduced proportion of DC-SIGN⁺ cells, downregulation of co-stimulatory molecules (MHC-II, CD80, and CD86) and key Th2-promoting factors (Jagged-1, OX40L), coupled with impaired phagocytosis and a reduced capacity to stimulate naïve CD4⁺ T cell proliferation. Crucially, HDM- and mannose-induced DCs effectively promoted the differentiation of naïve CD4⁺ T cells into Foxp3⁺ regulatory T (Treg) cells, demonstrating their direct role in actively enforcing immune tolerance. Adopti

SUBMITTER: Wang F 

PROVIDER: S-EPMC12751434 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature