Efficacy and safety of periodontal initial therapy combined with intralesional betamethasone sodium phosphate injection under local anesthesia in managing erosive oral lichen planus: study protocol for a multi-center, split-mouth, randomized self-controlled trial.

ABSTRACT:

Introduction

Erosive oral lichen planus (OLP) and periodontitis frequently coexist and may worsen each other. This study will evaluate the effectiveness and safety of combining periodontal initial therapy under local anesthesia with intralesional betamethasone sodium phosphate (BSP) injection in patients with erosive OLP, particularly in enhancing lesion healing.

Methods and analysis

This is a multicenter, randomized, split-mouth, self-controlled trial. We will recruit 29 adults from five tertiary centers in China. Eligible participants are adults (aged ≥ 18 years) diagnosed with erosive gingival OLP accompanied by generalized periodontitis (stage II-IV). Within each participant, sides will be randomly allocated to a test side (periodontal initial therapy under local anesthe

SUBMITTER: Chen H 

PROVIDER: S-EPMC12751475 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature