Tagatose consumption provokes metabolic syndrome features in rat males from mothers that consumed fructose during their pregnancy.

ABSTRACT:

Background

Maternal fructose intake induces harmful effects in progeny. However, this sugar is not contraindicated during pregnancy. On the other hand, the use of low-calorie sweeteners, such as tagatose, is increasing. Thus, we have studied whether the consumption of tagatose compared to fructose affects lipid metabolism in the offspring of mothers which were supplemented with fructose during their pregnancy.

Methods

Three-month-old male rat offspring from control or fructose mothers received liquid 10% fructose or tagatose for 21 days. A control group (without any additive) was also included. Biochemical and molecular parameters were determined in plasma, tissues and feces.

Results

Both tagatose and fructose consumption caused hypertriglyceridemia in descendants of

SUBMITTER: Fauste E 

PROVIDER: S-EPMC12751481 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature