Epidemiological trends of burden of brain and CNS cancer at global, regional, and national level: a trend analysis study from 1990 to 2021.

ABSTRACT:

Background

Brain and central nervous system (CNS) cancers, though relatively rare, contribute substantially to neurological disability and cancer-related mortality worldwide. This study systematically assessed their global, regional, and national trends from 1990 to 2021 and projected burden through 2035 using Global Burden of Disease Study (GBD) 2021 data.

Methods

Using data from the Global Burden of Disease (GBD) 2021 study, we estimated age-standardised incidence rate (ASIR), prevalence rate (ASPR), death rate (ASDR), and DALY rate across 204 countries, 21 regions, and five socio-demographic index (SDI) groups. Trends were analyzed using estimated annual percentage change (EAPC), and future projections were generated using a Bayesian age-period-cohort (BAPC) model.

Res

SUBMITTER: Chen L 

PROVIDER: S-EPMC12751487 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature