Impact of low-density lipoprotein cholesterol-lowering therapy on intermediate stenosis in non-culprit vessels of acute coronary syndrome.

ABSTRACT:

Background

Associations between optimal low-density lipoprotein cholesterol (LDL-C) level and changes in coronary flow and plaque characteristics are unclear. Therefore, we examined the effect of LDL-C lowering changes lipid-rich coronary plaques and flow using near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) and quantitative flow ratio (QFR) in non-culprit vessels of patients with acute coronary syndrome (ACS).

Methods

We prospectively examined 72 patients with ACS who underwent NIRS-IVUS for intermediate stenosis in non-culprit vessels at baseline and at follow-up. According to patients' LDL-C levels at follow-up, they were classified into two groups. Patients with LDL-C levels < 55 mg/dL were categorized into the very low LDL-C group (VL group), while those

SUBMITTER: Kakehi K 

PROVIDER: S-EPMC12751503 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature