Tertiary lymphoid structures are associated with lower axillary residual nodal burden in breast cancer patients after neoadjuvant chemotherapy.

ABSTRACT:

Background

Tertiary lymphoid structures (TLSs) are associated with an improved chemotherapy response and favorable clinical outcomes in various tumor types, including breast cancer. The number of TLSs increases in breast cancer after neoadjuvant chemotherapy (NAC), potentially activating the immune landscape of the tumor microenvironment. However, the potential relationship between TLSs and clinicopathological characteristics in patients with breast cancer after receiving NAC is poorly understood.

Methods

This retrospective study included clinicopathological data from breast cancer patients treated at Sun Yat-Sen Memorial Hospital between 2012 and 2023. Hematoxylin‒eosin staining and immunohistochemical analysis were performed to evaluate TLSs and lymphatic vessels in two co

SUBMITTER: Wei Z 

PROVIDER: S-EPMC12751520 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature