Circulating T-cell receptor repertoire and clinicopathological correlations in breast cancer patients: immune repertoire analysis from the VGH-TAYLOR study.

ABSTRACT: Sequencing of the T-cell receptor (TCR) repertoire can reflect immune status and monitor treatment responses. Here, we aimed to characterize the TCRβ repertoire and its correlation with clinical and prognostic significance in breast cancer. A total of 856 peripheral blood samples were collected from female breast cancer patients for TCR sequencing. At baseline, TCR clonality was elevated in patients with stage IV disease compared with earlier-stage breast cancer, and higher clonality within the stage IV cohort was associated with poorer overall survival. Compared with the luminal A subtype, luminal B2 breast cancer exhibited lower baseline TCR Shannon diversity. Following both adjuvant and neoadjuvant chemotherapy, we observed increased TCR convergence and clonality accompanied by reduced

SUBMITTER: Tseng LM 

PROVIDER: S-EPMC12751562 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature