Systolic and diastolic blood pressure, abdominal obesity, and alcohol consumption contribute to the risk of hypertrophic and dilated cardiomyopathies in European and East Asian populations.

ABSTRACT:

Background

Potentially modifiable cardiovascular risk factors, including hypertension, diabetes, obesity, alcohol consumption, and smoking initiation, are associated with hypertrophic (HCM) and dilated (DCM) cardiomyopathies, representing promising targets for interventions. However, the causality and cross-ancestry generalizability of these associations remain uncertain.

Methods

Collecting summary-level data from genome-wide association studies for systolic (SBP) and diastolic (DBP) blood pressure, hypertension, type 2 diabetes, fasting glucose, glycated hemoglobin, body mass index (BMI), waist circumference (WC), alcohol consumption, smoking initiation, HCM, and DCM (sample size ranging from 38,288 to 1,812,017), we performed comprehensive two-sample univariable Mendelian

SUBMITTER: Zhang W 

PROVIDER: S-EPMC12751570 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature