Potential mechanism underlying HXSJ decoction in the treatment of venous leg ulcers: based on the association between venous leg ulcers and ferroptosis.

ABSTRACT:

Background

Venous leg ulcer (VLU) is among the most severe clinical manifestations of chronic venous disease (CVD) and imposes substantial burdens on both patients and society. VLU pathogenesis is closely associated with the impairment of vascular endothelial cells. In this study, tissue samples from the patients' s skins around wound at different stages of CVD were collected during operation and used to elucidate the involvement of ferroptosis in the pathogenesis of VLU. Also the potential mechanism through which Huoxue Shengji (HXSJ) decoction alleviates ferroptosis in human umbilical vein endothelial cells (HUVECs) was investigated.

Methods

During surgical procedure such as great saphenous vein high ligation and stripping surgery, matched skin tissues from the normal, hyp

SUBMITTER: Pan S 

PROVIDER: S-EPMC12751643 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature