Emergence and regional evolution of Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae ST11 in China.

ABSTRACT:

Objectives

Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) sequence type (ST) 11 has emerged as a significant public health threat in China, yet its endemic population and evolutionary dynamics remain incompletely understood. To address this, we investigated the national distribution and local evolution of KPC-KP ST11 in China.

Methods

Our analysis included 4,262 KPC-KP ST11 genomes, comprising 56 isolates from a Guangdong hospital and 4,206 publicly available genomes. The genomic analysis encompassed population structure, genome annotation, and evolutionary dynamics, and was conducted on all sequenced genomes.

Results

Using a threshold of 10 core genome allelic differences, hierarchical clustering revealed 456 lineages, highlighting substan

SUBMITTER: Ma Z 

PROVIDER: S-EPMC12751682 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature