The construction of the gelatin methacrylate microneedle -encapsulated newcastle disease virus and its antitumor effect in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is associated with one of the highest cancer-related mortality rates worldwide and remains therapeutically challenging. There is an urgent need for innovative treatment strategies. Although Newcastle disease virus (NDV) has demonstrated potent oncolytic activity in vitro and in animal models, free virions administered intravenously are rapidly neutralized by pre-existing antibodies and exhibit poor tumor tropism, significantly limiting their clinical translation (Shalhout et al., Nat Rev Clin Oncol 20(3):160-177, 2023).

Objectives

This study aimed to develop porous gelatin methacrylate (GelMA) microneedles (MNs) for encapsulating Newcastle disease virus (NDV) and to evaluate their antitumor efficacy against HCC.

Methods

GelMA

SUBMITTER: Li T 

PROVIDER: S-EPMC12751726 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature