Cyclooxygenase-2 expression in advanced oral squamous cell carcinoma: a biomarker of poor prognosis.

ABSTRACT:

Objectives

The primary aim of this study was to evaluate the impact of cyclooxygenase-2 (COX-2) expression on overall survival (OS), local recurrence-free survival (LRFS), and regional recurrence-free survival (RRFS) in patients diagnosed with advanced oral squamous cell carcinoma (AOSCC).

Materials and methods

COX-2 expression levels were assessed in 191 cases of AOSCC and 50 cases of normal mucosa using immunohistochemistry (IHC). Comparisons were made between COX-2 expression in AOSCC and normal mucosal tissues, as well as its influence on OS, LRFS, and RRFS. The Cancer Genome Atlas (TCGA)- Head and Neck Squamous Cell Carcinoma (HNSC) database was utilized for validation.

Results

In this cohort of 191 patients with AOSCC followed for 1-145 months (median: 68.3 mont

SUBMITTER: Chen X 

PROVIDER: S-EPMC12751741 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature