Brain-behavior relationships in task-based fMRI assessments of executive functions in children and adolescents with and without ADHD: a systematic review and ALE meta-analysis.

ABSTRACT:

Background

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder affecting about 5% of children and adolescents worldwide. ADHD symptoms often reflect impairments in executive functions (EFs). Functional magnetic resonance imaging (fMRI), particularly task-based fMRI (tb-fMRI), has been crucial in studying the neural mechanisms behind ADHD and its EF deficits. However, few studies have examined differences in brain activation and behavioral outcomes between children with and without ADHD using tb-fMRI, or the correlation between brain activation and behavior.

Methods

This meta-analysis aimed to summarize evidence using activation likelihood estimation (ALE) analysis to identify differences in EFs and brain activation during tb-fMRI between c

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12751750 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature