Mediating effects of maternal blood lipids and glucose on the relationship between pre-pregnancy body mass index and newborn birth weight in women with gestational diabetes mellitus.

ABSTRACT:

Background

The effect of maternal blood lipids and glucose on the relationship between pre-pregnancy body mass index (BMI) and newborn birthweight (NBW) in pregnant women with gestational diabetes mellitus (GDM) remains unclear. This study aimed to examine whether maternal blood lipids and glucose mediate the relationship between pre-pregnancy BMI and NBW in pregnant women with GDM.

Methods

A retrospective study was conducted on 1257 women with GDM who gave birth at the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, between November 2017 and July 2021. Maternal blood lipids were measured at the first prenatal care (6-13 weeks of gestation). Glucoses, including mid-pregnancy fasting plasma glucose (FPG) and post-load glucose, were measured at 24-28 ges

SUBMITTER: Li H 

PROVIDER: S-EPMC12751765 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature