IFNL4-rs12979860 CC genotype predisposes to accelerated terminal exhaustion and senescence in HIV/HCV-chronic infection.

ABSTRACT:

Purpose

rs12979860 polymorphism of the lambda 4 interferon (IFNL4) gene has been related with Hepatitis C Virus (HCV) spontaneous clearance (CC genotype favourable versus CT/TT). The implications of this polymorphism over chronic-HCV disease are unknown, particularly during Human Immunodeficiency virus (HIV) coinfection.

Methods

Observational study in 118 people with HIV (PWH): 45 with HCV-chronic infection (CHC); 38 who spontaneously clear HCV (SC) and 35 never infected by HCV (HIV). Expression of surface markers was evaluated in CD4+ and CD8+ memory T cells by flow cytometry, and plasma markers were quantified by Luminex or ELISA.

Results

CHC individuals with CC genotype (CHC-CC) showed higher expression of markers suggestive of senescence (PD1/CD57) and activation

SUBMITTER: Arca-Lafuente S 

PROVIDER: S-EPMC12751784 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature