Uromodulin alleviates fibrosis in acute kidney injury to chronic kidney disease transition by reducing EGFR.

ABSTRACT:

Background

Uromodulin has been speculated as a protective factor for acute kidney injury (AKI) and chronic kidney disease (CKD), possibly based on the uromodulin-mediated cross-talk between thick ascending limbs and proximal tubules. Here, we explored the roles of uromodulin in the AKI-CKD transition.

Methods

Wild-type SD rats and UMOD^-/- rats were subjected to the AKI-CKD transition models. Cisplatin-stimulated HK-2 cells were treated with or without uromodulin. The renal injury and cell damage were evaluated.

Results

UMOD^-/- rats observed no spontaneous kidney injury and fibrosis. In two rat models of AKI-CKD transition, induced by repeated cisplatin nephrotoxicity and ischemia-reperfusion injury, UMOD deficiency exacerbated the kidney insuffic

SUBMITTER: Xing Z 

PROVIDER: S-EPMC12751814 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature