Trophoblast cell surface antigen 2 (TROP2) from ascitic extracellular vesicles drives peritoneal metastasis of ovarian cancer by mesothelial-to-mesenchymal transition.

ABSTRACT:

Background

Ovarian cancer (OvCA) exhibits a distinctive tendency toward peritoneal metastasis, a pathological process that greatly affects disease progression and postoperative recurrence. Understanding the biological mechanisms underlying this metastatic cascade is critical for improving prognosis and developing targeted therapeutic strategies. This study investigated the functional role of TROP2 in extracellular vesicles (EVs) from ovarian cancer ascites, and revealed how TROP2 induces mesothelial-mesenchymal transition (MMT) through EV-mediated intercellular communication. This process remodeled the mesothelial microenvironment into a pro-metastatic environment that enables peritoneal dissemination.

Methods

EVs were isolated from ascites and cell culture supernatants thro

SUBMITTER: Xie G 

PROVIDER: S-EPMC12751824 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature