Fiber length and shape-dependent differences in hepatic nanomaterial localization in mice following pulmonary exposure.

ABSTRACT:

Background

Inhaled nanomaterials can translocate from the lungs into systemic circulation and reach the liver, which is the main secondary organ for nanomaterial uptake, potentially causing adverse effects. Understanding how inhaled nanomaterials localize within liver tissue is important for understanding their clearance mechanisms and potential toxicity. Previous in vivo studies have primarily focused on spherical particles, highlighting the need for studies on fiber-shaped nanomaterials.

Methods

This study examines the hepatic distribution of five fiber-shaped nanomaterials (three multiwalled carbon nanotubes, gallium phosphide nanowires, and short TiO₂ nanotubes) compared to spherical TiO₂ nanoparticles. Liver samples were collected at 1, 3, 6, and 12 months after pulmona

SUBMITTER: Sundberg M 

PROVIDER: S-EPMC12751881 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature