Prospective association between the gut microbiota and incident pneumonia: a cohort study of 6419 individuals.

ABSTRACT:

Background

Previous animal studies have identified the protective capacity of the gut microbiota against respiratory infections. Nevertheless, the prospective association between human gut microbiota and pneumonia risk remains unknown.

Objectives

To evaluate the links between gut microbiota and incident pneumonia in a representative population sample.

Methods

We performed shotgun metagenome sequencing on stool samples from 6419 FINRISK 2002 participants. Participants were followed up for incident pneumonia using nationwide health register data. We employed multivariable-adjusted Cox regression models and permutational multivariate analysis of variance (PERMANOVA) to assess the association of gut microbiome alpha diversity, compositional variation (beta diversity), and

SUBMITTER: Wikki I 

PROVIDER: S-EPMC12751896 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature