Use of benzodiazepine receptor agonists in different pregnancy trimesters and risk of maternal and neonatal outcomes: a propensity weighted cohort study in Taiwan.

ABSTRACT:

Background

The association between benzodiazepine receptor agonist (BZRA) exposure and adverse perinatal outcomes remains inconclusive. This study aimed to assess the risks of adverse pregnancy and neonatal outcomes associated with maternal BZRA exposure across pregnancy trimesters.

Methods

Data from 170,144 maternal BZRA users and 1,098,172 nonusers were obtained from the Taiwan's National Health Insurance database. We used cross-sectional study design with inverse probability of treatment weighting (IPTW) to evaluate the association between maternal BZRA exposure during each trimester and adverse pregnancy outcomes. The pregnancy period was classified into 4 intervals: preconception, first trimester, second trimester, and third trimester. Logistic regression was performed

SUBMITTER: Yu RS 

PROVIDER: S-EPMC12751940 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature