Novel hypoxia-immune biomarkers predict response to neoadjuvant chemotherapy in patients with laryngo-hypopharyngeal cancer.

ABSTRACT:

Background

The hypoxic immune microenvironment has clinical significance in predicting sensitivity to neoadjuvant chemotherapy (NAC) in patients with laryngo-hypopharyngeal cancer (LHC).

Methods

In this study, RNA sequencing was performed to screen out differentially expressed genes (DEGs). Logistic regression analysis was used to construct a predictive model. Receiver operating characteristic (ROC) curves were used to evaluate the sensitivity and specificity. Kaplan-Meier survival analysis was conducted to investigate the differences in overall survival (OS) and progression-free survival (PFS) between different risk groups. Immune infiltration analysis was performed using the "ssGSEA" method. The association between biomarkers and drug sensitivity was assessed using the Cel

SUBMITTER: Wang L 

PROVIDER: S-EPMC12751945 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature