Per- and polyfluoroalkyl substances serum concentrations during pregnancy and gestational weight gain in the Healthy Start Study.

ABSTRACT:

Background

Per- and polyfluoroalkyl substances (PFAS) are widespread and persistent contaminants detected in most humans. PFAS exposure has been linked to adverse health conditions, including excessive gestational weight gain (GWG), though results have been inconsistent.

Methods

Participants (n = 539) were enrolled in the Healthy Start Study, a Colorado-based cohort (2009-2014). Eleven PFAS were measured in serum collected during pregnancy (median 27 weeks of gestation). GWG was quantified in four ways: absolute change in weight during pregnancy; GWG adjusted for the duration of pregnancy (z-score); 3rd trimester rate of weight gain; and categories of recommended GWG according to Institute of Medicine (IOM) guidelines. PFAS detectable in >60 % of samples (perfluorohexane sul

SUBMITTER: Kaplan JR 

PROVIDER: S-EPMC12751953 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature