Rethinking fetal central nervous system anomalies: predicting central nervous system anomalies with corpus callosum to head circumference and occipitofrontal diameter ratios.

ABSTRACT:

Background

Prenatal diagnosis of fetal central nervous system (CNS) anomalies remains challenging and is influenced by various factors, including imaging equipment quality, and access to advanced modalities such as fetal magnetic resonance imaging (MRI). In resource-limited settings, these constraints highlight the need for practical and accessible screening methods. This study aims to evaluate the predictive value of the fetal corpus callosum length-to-head circumference (CCL/HC) and corpus callosum length-to-occipitofrontal (CCL/OFD) diameter ratios in the detection of fetal central CNS abnormalities.

Materials and methods

This prospective cohort study included 243 singleton pregnancies undergoing routine mid-trimester ultrasound between November 2024 and May 2025. 15 fetu

SUBMITTER: Duymus AC 

PROVIDER: S-EPMC12751968 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature