Uncovering new MicroRNAs linked to acute pancreatitis: zeroing in on the protective effect.

ABSTRACT:

Background

The microRNA expression profile in the bodily fluids of individuals with acute pancreatitis (AP) undergoes considerable alterations; nevertheless, the precise mechanism requires more elucidation.

Methods

A dataset of 2083 human blood microRNAs (miRNAs) was obtained from the miRNA expression quantitative loci data. The genome-wide association study data for AP was obtained from the FinnGen Consortium. The causal association between miRNA and susceptibility to AP was evaluated using the Mendelian randomization (MR) method. Receiver operating characteristic (ROC) curve analyses were implemented to assess the miRNA's clinical usefulness. The GSE188819 and GSE249349 datasets were analyzed to determine changes in cell subset amounts and differentially expressed genes du

SUBMITTER: Zhao C 

PROVIDER: S-EPMC12751974 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature