PBX1 promotes osteoporosis by upregulating HMGB1 to suppress osteogenic differentiation of bone marrow mesenchymal stem cells.

ABSTRACT:

Background

Osteoporosis is a common skeletal disorder characterized by low bone mass and impaired bone formation, driven in part by defective osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).

Methods

Transcriptomic profiling, molecular biology techniques, functional assays, and pharmacological inhibition were used to investigate the regulatory role and downstream effects of candidate genes during BMSC osteogenic differentiation.

Results

Transcriptome-based screening identified Pre-B-cell leukemia homeobox 1 (PBX1) as a candidate gene consistently upregulated in samples with low bone mass. During osteogenic induction, PBX1 expression declined progressively, inversely correlating with classical osteogenic markers. Functional experiments demonstra

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12751999 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature