Clinicopathological and prognostic implications of OPMDs in oral squamous cell carcinoma: a 17-Year retrospective cohort study.

ABSTRACT:

Objectives

To characterize the clinicopathologic features of patients with oral squamous cell carcinoma (OSCC) and evaluate the prognostic significance of the history of oral potentially malignant disorders (OPMDs) in this population.

Materials and methods

This retrospective, single-center study enrolled 1140 patients from 2000 to 2017 to explore the clinicopathologic features of OSCC patients. After 2:1 propensity score matching, 129 patients with OPMD history (OPMD group) and 258 patients without OPMD history (non-OPMD group) were analyzed in a cohort study. The primary endpoint was overall survival (OS), while the secondary endpoint included disease-specific survival (DSS).

Results

Among the 1140 OSCC patients, only 17.0% had a well-documented history of OPMDs. The

SUBMITTER: Wang J 

PROVIDER: S-EPMC12752009 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature