Dataset Information
Minoxidil ameliorates myelodysplastic syndrome by targeting Wnt4 while sparing normal hematopoiesis.
Ontology highlight
ABSTRACT:
SUBMITTER: Shi X
PROVIDER: S-EPMC12752016 | biostudies-literature | 2025 Dec
REPOSITORIES: biostudies-literature
Publications
Minoxidil ameliorates myelodysplastic syndrome by targeting Wnt4 while sparing normal hematopoiesis.
Cell communication and signaling : CCS 20251222 1
BACKGROUND: Hematopoietic stem cells (HSCs) maintain blood production via tightly regulated differentiation. Disruptions at this level can lead to myelodysplastic syndromes (MDS), characterized by ineffective hematopoiesis and marrow failure. Despite its clinical use, the antihypertensive and hair-growth agent minoxidil has been linked to hematologic side effects, yet its mechanism remains unknown. METHODS: Compounds affecting hematopoiesis were identified by a small-molecule screen using Tg(mpl ...[more]
