Comprehensive surveillance of MicroRNA to discriminate between muscle-invasive and non-muscle-invasive urothelial carcinoma based on noninvasive urinary small RNA sequencing in Taiwanese patients.

ABSTRACT:

Background

Muscle-invasive urothelial carcinoma (MIUC) poses higher risks of recurrence and metastasis compared with non-muscle-invasive urothelial carcinoma (NMIUC). However, difficulties in early detection and the invasive nature of current diagnostic procedures. Using next-generation sequencing (NGS), we aimed to profile comprehensive surveillance of urinary microRNAs (miRNAs) as a promising non-invasive tool for assessing urothelial carcinoma (UC) and identify differentially expressed miRNAs (DEmiRNAs) in patients with MIUC or NMIUC, providing insights into UC progression and molecular mechanisms in Taiwanese patients. We analyzed the clinical differences between patients with MIUC or NMIUC in treatment-naïve patients.

Methods

Urinary miRNAs were profiled using NGS. DEmi

SUBMITTER: Yang IN 

PROVIDER: S-EPMC12752029 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature