IGFBP1 facilitates tumor proliferation, invasion and migration by modulating the MAPK-ERK signaling pathway in lung adenocarcinoma.

ABSTRACT:

Objective

Lung adenocarcinoma (LUAD) is the most prevalent histological subtype of lung cancer, and lymph node metastasis serves as a significant prognostic risk factor. The identification of molecular biomarkers associated with lymph node metastasis holds paramount importance in the prevention and treatment strategies for this condition.

Methods

Through bioinformatic analysis, we identified insulin-like growth factor binding protein 1 (IGFBP1) as the biomarker most strongly associated with lymph node metastasis. Subsequently, we performed proliferation, invasion, and migration assays using IGFBP1-overexpressing and knockdown cell lines. The single-cell-RNA-sequence data indicated that IGFBP1 facilitates the progression of LUAD cells through the MAPK signaling pathway. Subse

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12752103 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature