Trends in Liver Transplantation for Acute Liver Failure in a Spanish Multicenter Cohort.

ABSTRACT:

Background and aims

Acute liver failure (ALF) is a rare and severe condition with high mortality. Liver transplantation (LT) has improved patient outcomes. This study analysed trends in aetiology, characteristics, and outcomes of ALF patients undergoing LT in Spain.

Methods

We retrospectively reviewed 217 adult ALF-LT cases from 11 Spanish centers (2001 -2020), divided into two 10-year periods. Clinical, biochemical, and outcome data were collected, and predictors of mortality were identified.

Results

217 adult ALF-LT patients were included (61.8% women, mean age: 41 years). Common aetiologies were cryptogenic (26.7%), autoimmune (26.3%), and viral (18%), with sex differences. Over time, autoimmune and drug-induced liver injury increased (22.3% vs 29.8% and 13.6% vs 2

SUBMITTER: Conde Amiel I 

PROVIDER: S-EPMC12752109 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature