Quantification of the IgG antibody response half-life for hybrid immunity to SARS-CoV-2.

ABSTRACT:

Background

A firm understanding of SARS-CoV-2 hybrid immunity is crucial for our ongoing efforts to protect people from severe and fatal disease and assess population vulnerability to emerging novel variants. As many components of the immune response are unobserved and complex to investigate, some ambiguities and unanswered questions remain about hybrid immunity to COVID-19, such as the duration of the antibody response in individuals.

Methods

To address this, we evaluated longitudinal data that spanned up to 21 months from 52 SARS-CoV-2 naive individuals and 88 SARS-CoV-2 recovered individuals. We further separated individuals according to whether they received an mRNA or non-mRNA vaccine for their primary two-dose vaccinations. A hierarchical Bayesian framework was used to

SUBMITTER: Bongiovanni F 

PROVIDER: S-EPMC12752168 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature