Bushen Huatan formula alleviates polycystic ovary syndrome in rats by activating the PI3K/Akt pathway to inhibit GSDMD-mediated pyroptosis and mitochondrial damage.

ABSTRACT:

Background

Previous studies suggest that the traditional Chinese medicinal formula Bushen Huatan Fang (BSHT) possesses the capacity to modulate hormonal levels in patients with endocrine and metabolic disorders, indicating its potential clinical utility. This study aims to elucidate the specific mechanisms through which BSHT exerts therapeutic effects in a rat model of polycystic ovary syndrome (PCOS).

Methods

A PCOS model was established in female Sprague-Dawley rats using a high-fat diet and letrozole. Rats were randomly assigned to control, model, positive control (metformin), and BSHT low dose (BSHT-L), medium dose (BSHT-M), and high dose (BSHT-H) groups, with interventions administered for 31 days. Endocrine markers (follicle-stimulating hormone (FSH), luteinizing hormo

SUBMITTER: Xiong Q 

PROVIDER: S-EPMC12752174 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature