Impact of skeletal muscle mass index on glycemic progression and remission in Chinese adults with prediabetes: a nationwide cohort study.

ABSTRACT:

Background

Age-related decline in skeletal muscle mass among middle-aged and older adults is a major global public health concern and a critical factor affecting glucose metabolism. This study aims to investigate the association between the skeletal muscle mass index (SMI) and glycemic progression and remission in the middle-aged and older Chinese population with prediabetes.

Methods

We conducted a nationwide prospective cohort study among Chinese adults aged ≥ 45 years. Individuals with prediabetes and their glucose outcomes were defined according to the American Diabetes Association criteria. Cox regression models and restricted cubic spline regression models were applied to evaluate the association between SMI and the progression or remission of individuals with prediabet

SUBMITTER: Wan J 

PROVIDER: S-EPMC12752229 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature