Analysis of immune-related biomarkers in amniotic fluid embolism by sequencing data and bioinformatics.

ABSTRACT:

Background

Amniotic fluid embolism (AFE) represents an uncommon yet life-threatening obstetric emergency characterized by its sudden onset and significant contribution to maternal death. Immune dysregulation has been implicated as a key pathological mechanism in AFE progression. This investigation employed through comprehensive bioinformatics approaches transcriptomic profiling of clinical specimens to systematically identify immune-associated genetic alterations that can distinguish AFE - induced pulmonary embolism from normal controls.

Methods

We conducted RNA sequencing on clinical specimens to delineate differentially expressed genes associated with AFE pathogenesis and immune responses. Functional annotation and protein-protein interaction (PPI) networks were generated

SUBMITTER: Ma J 

PROVIDER: S-EPMC12752267 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature