Survival patterns and mutation profiles in never- and light-smokers with stage IV NSCLC.

ABSTRACT:

Background

Up to 15% of NSCLC cases arise in never-smokers, and an additional subset arises in light smokers. Data on these groups in the Middle East are limited. Therefore, we compared the clinicopathological features, survival, and molecular alterations in never and light smokers with stage IV NSCLC treated at a tertiary center in Jordan.

Methods

We retrospectively reviewed data from January 2015 to December 2023. Never-smokers were defined as those who had smoked < 100 lifetime cigarettes, and light smokers as those who had smoked < 5 pack-years. Survival rates and prognostic variables were estimated using Kaplan-Meier analysis and univariate Cox models.

Results

Among 190 patients (median age 54 years), 159 were never smokers and 31 were light smokers. Never smoker

SUBMITTER: Alqasem K 

PROVIDER: S-EPMC12752286 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature