Continuous-time random walk diffusion MRI facilitates assessment of Ki-67 expression in endometrial cancer: a comparative study with diffusion kurtosis imaging.

ABSTRACT:

Objectives

This study aimed to evaluate the performance of continuous-time random walk (CTRW), diffusion kurtosis imaging (DKI), and diffusion-weighted imaging (DWI) in predicting the proliferative state of endometrial cancer (EC).

Methods

A cohort of 81 EC patients was recruited. The parameters obtained from CTRW (α, β, and D_m), DKI (D_app, K_app), and DWI (ADC) were computed and compared between the high- and low-proliferation groups. Logistic regression analysis was used to identify independent predictors and perform a combined diagnosis. The area under the receiver operating characteristic curve (AUC), DeLong analysis, and calibration curves were used to assess the diagnostic performance.

Results

K_app was higher and α, β,

SUBMITTER: Liu W 

PROVIDER: S-EPMC12752295 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature