Multimodal neuroimaging insights into central mechanisms of overactive bladder with an empty bladder: a cross-sectional study.

ABSTRACT:

Background and objective

Overactive bladder (OAB) is a complex condition involving central nervous system (CNS) processes that are not fully understood. We conducted a detailed neuroimaging study to investigate the CNS role in OAB, focusing on the bladder emptying state.

Methods

This cross-sectional study included 168 OAB patients and 133 matched controls. Participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) during the bladder emptying state. Data were analyzed using tract-based spatial statistics (TBSS), graph theory, functional connectivity, and structure-function coupling. The Overactive Bladder Symptom Score (OABSS) and the Overactive Bladder Questionnaire Short Form (OAB-q SF) were also utilized.

Key

SUBMITTER: Feng Y 

PROVIDER: S-EPMC12752313 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature