Factors affecting voriconazole pharmacokinetic variability in critically ill patients: a systematic review.

ABSTRACT:

Background

The efficacy and toxicity of voriconazole, a broad-spectrum antifungal agent, are correlated with its trough concentration (C_trough). Patients hospitalised in the intensive care unit (ICU) frequently experience inadequate voriconazole exposure. We sought to identify factors associated with variability of voriconazole C_trough in ICU patients.

Methods

We searched MEDLINE, Web of Science and Cochrane Library databases from inception through July 2025.

Results

Thirty-one studies describing nine factors of variability were included. Liver dysfunction, high body mass index, high SOFA score and high inflammation status were associated with voriconazole overexposure, whereas the oral route of administration, renal replacement therapy and low b

SUBMITTER: Coste A 

PROVIDER: S-EPMC12752375 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature