TMEM88 modulates the proliferation and metastasis of HCC via the GSK-3β/β-catenin pathway.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is one of the most frequent and deadly tumors worldwide. Despite advances in targeted and immunotherapy, its overall survival rates remain low.TMEM88 has drawn a lot of attention for its roles in various cancers; nevertheless, its exact function and mechanisms in HCC are still unknown.

Methods

TMEM88 expression was analyzed in 72 HCC tumors vs. adjacent tissues via qPCR/Western blot. Clinical correlations with survival, AFP, and grading were assessed. Functional assays (proliferation, migration, cell cycle) and Wnt/β-catenin signaling (GSK-3β/β-catenin) were evaluated in vitro. Tumor growth was validated in xenografts.

Results

This study discovered that patients with high TMEM88 expression had significantly improved overall su

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12752382 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature