Subphenotypes of mechanically ventilated acute respiratory distress syndrome patients based on multi-dimensional pathophysiological parameters.

ABSTRACT:

Background

Acute respiratory distress syndrome (ARDS) is a life-threatening condition with significant heterogeneity in pathophysiology. The integration of pulmonary edema indices, respiratory mechanics, and gas exchange parameters to define subphenotypes in mechanically ventilated patients with ARDS has not yet been investigated.

Methods

We conducted a post hoc analysis of a prospective observational study with a derivation cohort (n = 111). We applied K-means clustering to identify distinct subphenotypes based on key physiological parameters: pulmonary edema indices, respiratory mechanics, and gas exchange variables. The primary outcome was 28-day mortality. Between-group differences in 28-day mortality were analyzed using the chi-square test. Survival analysis was perform

SUBMITTER: Li L 

PROVIDER: S-EPMC12752403 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature