PTDSS1 serves as a prognostic biomarker of macrophage infiltration in pan-cancer and promotes hepatocellular carcinoma malignant phenotypes.

ABSTRACT:

Background

Phosphatidylserine synthase 1 (PTDSS1) inhibitor has been developed and shows promising anti-tumor effect, but existing studies about PTDSS1 remain limited in cancer.

Methods

This study preliminarily analyzed the differential expression, prognostic significance, copy number variation, methylation level, co-expression network and immune correlation of PTDSS1 in pan-cancer. Furthermore, we collected tumor samples and corresponding clinical information of 74 hepatocellular carcinoma (HCC) patients from the First Hospital of Guangxi Medical University (Guangxi cohort) to validate PTDSS1 expression and prognostic value. In vitro experiments were performed to investigate the effect of PTDSS1 knockdown on the malignant phenotypes of HCC cell lines.

Results

This st

SUBMITTER: Lan C 

PROVIDER: S-EPMC12752422 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature