Human papilloma virus genotypes associated with non-cervical HPV positive cancer development in UK and Ireland cohorts: a systematic review.

ABSTRACT:

Background

Human Papillomavirus (HPV) is an infectious agent notably associated with viral carcinogenesis of the cervix. Since 2019, the UK and Ireland have used the Gardasil-9 HPV vaccine to prevent new cases of HPV-positive cancers. This systematic review aims to assess whether the current HPV vaccination programme provides substantive protection against developing non-cervical HPV-positive cancers.

Methods

Relevant studies were identified using the OVID-Medline and EMBASE databases. Screening and data extraction were conducted using the systematic review software Covidence. Risk of bias was assessed using the Hoy et al. tool, and statistical analysis was conducted using R statistical software (v 4.3.1).

Results

Based on pre-defined search parameters, 4,086 papers w

SUBMITTER: Mallon M 

PROVIDER: S-EPMC12752435 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature